Evaluate the value of prolonging the duration of tiopronin for injection administration in preventing hepatotoxicity

Abstract

Abstract purpose：As part of supportive therapy, prophylaxis with tiopronin for injection (TI) against common hepatotoxicity complications has often been used. However, methods to prevent hepatotoxicity have not been established. Therefore, we analyzed the relationship between the periods of TI prophylaxis and its efficacy in preventing hepatotoxicity,evaluate the value of prolonging the duration of TI administration in preventing hepatotoxicity in gynecological cancer patients. Methods This is a retrospective study. During 2022.1–2023.3, 452 patients with gynecological cancer patients were included in this study，the patient had normal liver function tests before treatment. The influencing factors of liver toxicity after treatment were analyzed, and different subgroups were divided according to the influencing factors. In total sample and different subgroups, we evaluated the prophylactic efficacy of TI by comparing the number of days of TI use. and the difference of the number of days of TI use on the prognosis of patients was compared in the total samples. Results In total samples, there was no significant difference the effectiveness of TI with different prevention days for hepatotoxicity (P>0.05), and there was no significant difference in prognosis of tumor (P>0.05). The influencing factors of hepatotoxicity were the combinations of chemotherapeutic drugs,duration of chemotherapy drug use and the previous hepatotoxicity of patients. In different subgroups, there was no significant difference the effectiveness of TI with different prevention days for hepatotoxicity (P>0.05). Conclusion TI is used as prophylactic drug in gynecological cancers, and prolonging periods of administration has no clinical value in preventing hepatotoxicity.