Relationship between cancer stem cell-related SNPs and survival outcomes in patients with primary lung cancer

Abstract

Abstract Background: Stem cells may be the source of cancer-causing mutant cells and are closely related to the prognosis of cancer. Our study aim to investigate the association between single nucleotide polymorphisms of cancer stem cell related genes and prognosis of lung cancer patients. Methods: Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) was used to genotype SNPs loci. Log-rank test was used to analyze and compare the difference of total survival time among different demographic data, clinical data and genotypes. Cox regression model was used to analyze the correlation between survival time and quality of life of lung cancer under codominant, dominant, recessive and additive genetic models. Test levelα=0.05. Results: Stratified analysis showed that rs3740535 had recessive AA genotype and additive GG genotype. Rs3130932 Dominant GT+GG genotype, additive TT genotype; Rs13409 additive TT genotype; Rs6815391 recessive CC genotype and additional TT genotype were associated with increased risk of lung cancer death. Rs3130932 recessive GG genotype was associated with reduced risk of lung cancer death. Conclusion: Rs3130932, rs13409 and rs6815391 are associated with the prognosis of lung cancer patients, and can affect the prognostic survival time of lung cancer patients.