Application of low-intensity anticoagulation after On-X mechanical aortic valve replacement
Author:
Affiliation:
1. Mianyang Central Hospital
2. Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Affiliated Hospital of University of Electronic Science and Technology
Abstract
Objective To explore the safety and efficacy of low-intensity anticoagulation in patients after On-X mechanical aortic valve replacement. Methods This study retrospectively collected data from patients diagnosed with aortic valve disease (stenosis or closed insufficiency) who underwent surgical On-X mechanical aortic valve replacement in the Cardiac Surgery Department of Sichuan Provincial People's Hospital from December 2018 to December 2021; the patients were divided into low intensity anticoagulation group (INR:1.5-2.0) and higher intensity anticoagulation group (INR:2.0-2.5) based on postoperative stable INR value (relatively stable INR for 3 months) to compare the incidence of postoperative anticoagulant-related adverse events in the two groups. Results Fifty-three patients were included in the low-intensity anticoagulation group (INR 1.5-2.0), and 51 patients were included in the higher-intensity group (2.0-2.5) in the baseline data and surgery (P > 0.05); the two groups were statistically significant in PT, INR and bleeding events (P < 0.05), but no significant difference in embolic adverse events (P > 0.05). Conclusion For patients requiring On-X mechanical aortic valve replacement who have no risk factors for thromboembolism, it is appropriate to control the INR in the target range 1.5-2.0, which can reduce the incidence of bleeding adverse events and significantly improve the quality of life, without increasing the risk of thromboembolic adverse events.
Publisher
Springer Science and Business Media LLC
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