The influence of kidney depth measured by computed tomography on glomerular filtration rate in patients with moderate and severe obstructive nephropathy

Author:

Ren Siyu1,Wu Airui1,Wen Xiaoxia1,Liang Wenli1,Zhao Deshan1

Affiliation:

1. The Second Hospital of Shanxi Medical University

Abstract

Abstract Purpose: This study aimed to evaluate the effect of CT for correcting the renal depth on the accuracy of GFR in the patients with moderate and severe hydronephrosis. Methods: Fifty five patients with hydronephrosis were studied. All the subjects were accepted the diuretic dynamic renal imaging, injected 99mTc-DTPA, and abdominal CT scanning after renal imaging. GFR in all patients were tested by two-sample plasma clearance method. The tønnesen's formula and CT were used to measure the kidney depths.According to tGFR, all the subjects were divided into 3 groups: (1)patients: GFR≥90 ml/min1.73m2; (2)patients: 60≤GFR<90 ml/min1.73m2; (3)patients: 0<GFR<60 ml/min1.73m2. All statistical analysis was done with SPSS statistics version 25.0. Results: In patients with moderate to severe hydronephrosis, the renal depths in normal and hydronephrotic kidneys measured by CT were significantly greater compared to Tønnesen formula(t=-6.61, t=-9.65, p<0.05, p<0.05). 2. In GFR ≥90 ml/min1.73m2 and 60≤GFR<90 ml/min1.73m2 groups, significant differences between gGFR and tGFR weren’t found , and dGFR was significantly higher than tGFR (t=-2.779, t=2.62, p=0.013, p=0.01). In GFR<60 ml/min1.73m2 group, significant differences between tGFR and all other GFRs were noted (t = 2.68, t = -4.33, p < 0.05, p < 0.05). 3. In the patients with moderate to severe hydronephrosis, there were statistically differences between dGFRsingle and gGFRsingle in normal and hydronephrotic kidneys (t=7.46, t=6.16, p<0.05, p<0.05). Conclusion: The CT-based renal depth-calibrated GFR could be more accurately used to evaluate the renal function in the patients with moderate-to-severe hydronephrosis. Key words: hydronephrosis; glomerular filtration rate; computed tomography; Gates method; kidney depth

Publisher

Research Square Platform LLC

Reference15 articles.

1. An overview of hydronephrosis in adults;Patel K;Brit J Hosp Med,2020

2. Reproducibility of differential renal function measurement using technetium-99m-ethylenedicysteine dynamic renal scintigraphy;Nguyen DL;Nucl Med Commun,2018

3. Feasibility of gamma camera-based GFR measurement using renal depth evaluated by lateral scan of 99mTc-DTPA renography;Sugawara S;Ann Nucl Med,2020

4. Development of a generalized model for kidney depth estimation in the Chinese population: A multi-center study;Li Q;Eur J Radiol,2020

5. Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system;Nguyen HT;J. Urol,2014

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3