Efficacy and Safety of a Proprietary Punica Granatum Extract in a Randomized, Placebo-Controlled Clinical Study in Healthy Volunteers

Abstract

Abstract Quality of life of individuals are closely linked to the health of one’s skin and the way our skin looks is the hallmark of normal aging. Clearly, healthy and glowing skin is no longer the job of traditional cosmetics alone. Therefore, the concept of beauty from within is a growing trend in the market and people now look for oral supplements that can enhance the well-being of skin from within. In this connection, a proprietary pomegranate extract (Grantria®), standardized to ellagic acid, punicic acid and punicalagin, developed using ADOP technology was clinically evaluated for its efficacy and safety in healthy adults. The evaluation was carried out as a randomized, placebo-controlled clinical study for 60 days at a daily dose of 300 mg. Results of the study indicated that the Punica granatum extract significantly reduced crow’s feet wrinkles, tactile roughness, forehead fine lines, forehead wrinkles and improved skin radiance compared to the placebo in 60 days. Other skin health attributes like pores, spots and UV pigmentation were also observed to exhibit significant changes .The test group shown a significant improvement in skin tone evenness, skin moisturisation, elasticity and firmness compared to the baseline. The Tyrosinase biomarker levels observed to have a drop of 3% in the Grantria® supplemented group. In conclusion, Grantria® was found to be effective, safe and well accepted by the subjects making it a potential candidate for use in the supplements intended for maintaining healthy and glowing skin.