Comprehensive analysis to investigate the association between IL-8 gene polymorphisms and the risk of cancer from 135 case-control studies

Abstract

Abstract Background The association between polymorphisms in the interleukin-8 (IL-8) gene and the development of cancer risk have been investigated in many studies. Nonetheless, the past findings have needed to be more consistent and conclusive. Thus, the current study aims to comprehensively evaluate the association between IL-8 gene polymorphisms and cancer risk. Methods The literature survey was conducted across multiple databases. The search comprised all relevant publications conducted on June 23, 2023. Results In accordance with the predefined search criteria for assessing cancer susceptibility, an inclusive meta-analysis was conducted, containing 135 case-control studies. This investigation yielded a collection of six distinct polymorphisms (-251, -353, + 678, +1633, + 2767, +781), which were identified and documented. The association strength was evaluated via odds ratios with 95% confidence intervals. This research has made a significant discovery regarding the − 251 polymorphism and its potential association with increased cancer risk. The resulting analyses encompassed various populations, including Asians and individuals of mixed ancestry, as well as different sources of control, precisely hospital-based sources. Furthermore, the study examined multiple types of cancer, such as gastric, glioma, bladder, and colorectal. These examinations suggest that the − 251 polymorphism may have been implicated in elevating the susceptibility to these malignancies. The − 353 polymorphism was identified as a potential risk factor that indicated its involvement in cancer development, while the + 781 polymorphism was also linked with elevated cancer risk. Conclusions Overall, the investigation has revealed that IL-8 gene polymorphisms significantly influence vulnerability to cancer development.