Exploring Cancer Patients’ Perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN) Experiences and Its Management: A Qualitative Study

Abstract

Abstract Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common side effects of chemotherapy that can lead to poor quality of life among cancer patients. Currently, no strong and effective CIPN preventive measures exist, while treatment options available are limited. This study aimed to explore CIPN experience among Malaysian cancer patients and potential barriers to its management. Methods: Semi-structured one-to-one interviews were conducted among cancer patients with a confirmed diagnosis of CIPN. Interviews were audio-recorded, transcribed verbatim, and analysed using thematic analysis. Results: Twenty-two participants were included in the interviews, with a predominant representation of females (n=12) and primary diagnosis of colon cancer (n=8). Most participants received platinum-based chemotherapy, primarily oxaliplatin (n=10). Twomajor themes emerged with three subsequent subthemes for each: (1) CIPN experiences (subthemes: CIPN symptoms and severity, CIPN tolerance, CIPN awareness) and (2) CIPN management (subthemes: choices of current treatment, effectiveness of treatment, option for a new treatment). The study results indicate that patients experienced CIPN, which was considerably mild and impacted their life activities to a small extent. Although the management of CIPN was able to partly control symptoms, patients experienced side effects from the prescribed medications. Despite this, patients expressed openness to explore new treatments to help them coping better with CIPN. Conclusion: The study's findings showed the need to manage patients’ understanding regarding CIPN. Current CIPN management among these patients was acceptable, however, their quality of life was impacted. By considering patients’ perspectives, these findings may help to enhance the management of CIPN.