Correlation of preoperative hematological markers with clinicopathological features of LSCC

Abstract

Abstract Objective This study aimed to examine the relationship between hematological markers and the detection and diagnosis of LSCC, the development of carcinoma, and their clinical importance. Methods Patients with LSCC were searched through the laryngeal cancer-specific database. Clinical data such as sex, age, clinical classification, T-stage, N-stage, pathological stage, smoking and drinking habits, blood routine, biochemical examination, and coagulation examination were collected, and all data were processed by SPSS 23.0 statistical software, and P < 0.05 was considered a statistically significant difference. Results Clinical classification and pathological stage were correlated with NLR, PLR, and LMR levels (P < 0.05). There was a correlation between the T stage and NLR levels (P < 0.05). There was a correlation between smoking and LMR level (P < 0.05). PLT levels were linked with age, T stage, N stage, and alcohol consumption (P < 0.05). T stage and N stage were connected with PDW levels (P < 0.05). Sex, clinical classification, and HB levels were associated (P < 0.05). Age, clinical classification, and N stage were connected with ALB level (P < 0.05). Age, clinical classification, pathological stage, T stage, N stage, and alcohol consumption were connected with PA level (P < 0.05). There was a correlation between sex and APTT level (P < 0.05). Clinical classification, T stage, and FIB level were associated (P < 0.05). Conclusion Increased levels of NLR, PLR, PLT, and FIB and decreased levels of LMR, MPV, PDW, HB, ALB, and PA are associated with poor clinicopathological features of LSCC. Hematological markers are important in monitoring cancer progression, guiding treatment, and predicting prognosis.