LncRNA MALAT1 regulates lymph node metastasis of triple-negative breast cancer through ceRNA mechanism-Reference-Cited by-同舟云学术

LncRNA MALAT1 regulates lymph node metastasis of triple-negative breast cancer through ceRNA mechanism

Published:2024-04-05 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Yang Qiu-hui¹,Fu Ye-qin¹,Feng Wei-liang¹,Yu Xing-fei¹,Xu Ning²,Yang Hong-jian¹,Zhang Xi-ping¹

Affiliation:

1. Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.

2. School of Medicine，Shaoxing University，Shaoxing，Zhejiang，312000，China

Abstract

Long non-coding RNA (LncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays an important role in the occurrence and development of cancer, but there are no relevant reports on the mechanism of MALAT1 in TNBC lymph node metastasis. Our study confirms that MALAT1 has a significant impact on the proliferation, invasion, and migration of TNBC cells, and MALAT1 may regulate TNBC cell metastasis through the competing endogenous RNA (ceRNA) mechanism of MALAT1/miR-106a-5p/REEP5 axis. In addition, prognostic analysis showed positive correlation between the expression level of MALAT1 and the degree of axillary lymph node metastasis in TNBC patients. This discovery is expected to provide new ideas for the diagnosis, and prognostic predicting of TNBC.

Publisher

Research Square Platform LLC

Reference32 articles.

1. Cancer statistics in China and United States, 2022: profiles, trends, and determinants;Xia C;Chin Med J (Engl),2022

2. Estimates of past and future time trends in age-specific breast cancer incidence among women in Karachi, Pakistan: 2004–2025;Zaheer S;BMC Public Health,2019

3. Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status;Rossing M;Sci Rep,2021

4. Pathogenesis of Triple-Negative Breast Cancer;Derakhshan F;Annu Rev Pathol,2022

5. EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis;Verma A;Nat Commun,2022