Unraveling the Interplay of Parasitaemia, Cytokines, and Pregnancy Outcomes in Plasmodium bergheiInfection: Insights from a Murine Model
Author:
Manhas Prem Lata1, Sehgal Rakesh2, Radotra Bishan Dass2, Mewara Abhishek2, Malhotra Pankaj1
Affiliation:
1. Postgraduate Institute of Medical Education and Research 2. Post Graduate Institute of Medical Education and Research
Abstract
Abstract
Malaria infection during pregnancy presents notable risks to both maternal and fetal health. Present study examines the impact of Plasmodium berghei NK-65 strain infection during different stages of pregnancy in mice. The study categorized mice into non-pregnant and pregnant groups (early, mid, and late pregnancy) and induced infection on specific gestation days. Parasitaemia, cytokine profiles, histopathological changes, and pregnancy outcomes were evaluated. Major findings include severe anemia in mid-pregnancy infection, fetal deaths in early and mid-pregnancy infections, stillbirths in mid-pregnancy infections, and premature deliveries in late-pregnancy infections. Cytokine profiles differed between pregnant and non-pregnant mice, indicating varied immune responses. Plasmodium berghei infection in pregnant mice provides valuable insights into understanding placental malaria and its implications for maternal and fetal health.
Publisher
Research Square Platform LLC
Reference18 articles.
1. Craig, A. G., Grau, G. E., Janse, C., Kazura, J. W., Milner, D., Barnwell, J. W., Turner, G., Langhorne, J., & on behalf of the participants of the Hinxton Retreat meeting on “Animal Models for Research on Severe Malaria.” (2012). The Role of Animal Models for Research on Severe Malaria. PLoS Pathogens, 8(2), e1002401. https://doi.org/10.1371/journal.ppat.1002401 2. Quantifying the Number of Pregnancies at Risk of Malaria in 2007: A Demographic Study;Dellicour S;PLoS Medicine,2010 3. Malaria in pregnancy: The relevance of animal models for vaccine development;Doritchamou J;Lab Animal,2017 4. Franke-Fayard, B., Janse, C. J., Cunha-Rodrigues, M., Ramesar, J., Büscher, P., Que, I., Löwik, C., Voshol, P. J., Den Boer, M. A. M., Van Duinen, S. G., Febbraio, M., Mota, M. M., & Waters, A. P. (2005). Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration. Proceedings of the National Academy of Sciences, 102(32), 11468–11473. https://doi.org/10.1073/pnas.0503386102 5. Of mice and women: Rodent models of placental malaria;Hviid L;Trends in Parasitology,2010
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