Safety and efficacy of exercise in patients with bone metastases: Systematic review and meta-analysis

Author:

Hu Chengzhe1,Yang Jiandong2,Liu Chen1,Zheng Zihao3,Zhong Mingkai3,Cui Fei4

Affiliation:

1. Medical College of Yangzhou University

2. Clinical Medical College of Yangzhou University/ Northern Jiangsu People's Hospital

3. Dalian Medical University

4. Northern Jiangsu People's Hospital

Abstract

Abstract Background: Cancer patients may enhance their physical function and quality of life via exercise. However, there are few quantitative data to determine if exercise is safe and effective for the patients with bone metastases.Methods: Embase, PubMed and Cochrane Controlled Trials Register Databases were searched to May 5, 2022.Results: 692 items were found. Five studies totaling 234 patients were included in the analysis after thorough screening. The interventions included soccer, aerobic exercise, and resistance training. There were no adverse effects connected to exercise. The results of the mixed-efficacy study showed that exercise improved bone mineral density more than regular nursing (P=0.009). It also had a clinically significant effect on body composition and pain, but there was no difference between the groups (P > 0.05).Conclusions: Exercise seems to be safe for people with bone metastases, and it can increase bone density, improve body composition, and alleviate pain.

Publisher

Research Square Platform LLC

Reference41 articles.

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4. Coleman, R., Bone-Targeted Agents and Metastasis Prevention. Cancers, 2022. 14(15).

5. Roviello, G., et al., Castration-resistant prostate cancer with bone metastases: toward the best therapeutic choice. Medical oncology (Northwood, London, England), 2022. 39(10): p. 145.

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