Comparative Visual Performance of Ultraviolet Light-filtering and Violet Light-filtering Monofocal Intraocular Lenses of the Same Material and Basic Design

Abstract

Abstract We compared the visual performance of ZCB00 ultraviolet light-filtering and ZCB00V violet light-filtering monofocal intraocular lenses (IOLs) (both Johnson & Johnson Surgical Vision) with the same materials and basic design in cataract patients treated in 2011-2020, with evaluations performed at 10 weeks following the last surgery for implantation of bilateral lenses ≤3 months apart. The ZCB00 and ZCB00V groups included 904 eyes from 452 patients (age 72.3±6.8 y; women/men, 268/184) and 1374 eyes from 687 patients (age 73.0±7.4 y; women/men, 415/272), respectively. Statistical validity was confirmed using a linear mixed-effects model with binocular data and adjustments for age, sex, subjective refraction cylinder, subjective refraction spherical equivalent, corneal astigmatism, axial length, pupil diameter, and corneal higher-order aberrations. ZCB00 showed slightly but significantly better results (p<0.05, Wald) for uncorrected intermediate/near visual acuity, corrected near visual acuity, and components of the 25-item Visual Function Questionnaire (VFQ-25) (Role_Limitation, Mental_Health, Social_Function, Distance_Vision, Color_Vision). Meanwhile, ZCB00V showed significantly better contrast sensitivity with glare (visual angle of target: 6.3°/4.0°/0.7°; p<0.00068, Wald); slightly but significantly better contrast sensitivity without glare (4.0°/2.5°/1.6°) and with glare (2.5°/1.6°/1.0°), VFQ-25 General_Health scores, and near spectacle independence; and slightly but significantly smaller higher-order aberrations (internal, scaled to a 6-mm pupil; Wavefront_6_post_I_Trefoil) (p<0.05, Wald).