Affiliation:
1. Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu
Abstract
Abstract
Background
The usefulness of static monitoring using central venous pressure has been reported for anesthesia management in hepatectomy. It is unclear whether intra-hepatectomy dynamic monitoring can predict the postoperative course. We aimed to investigate the association between intraoperative dynamic monitoring and post-hepatectomy complications. Furthermore, we propose a novel anesthetic management strategy to reduce postoperative complication.
Methods
From 2018 to 2021, 93 patients underwent hepatectomy at our hospital. Fifty-three patients who underwent dynamic monitoring during hepatectomy were enrolled. Flo Trac system was used for dynamic monitoring. The baseline central venous oxygen saturation was defined as the average central venous oxygen saturation for 30 min after anesthesia induction. Central venous oxygen saturation fluctuation was defined as the difference between the baseline and minimum central venous oxygen saturation. Postoperative complications were evaluated using the comprehensive complication index (CCI).
Results
Patients with central venous oxygen saturation fluctuation ≥ 10% had significantly higher CCI scores (0 vs. 20.9: p = 0.043). Patients with higher CCI scores demonstrated significantly higher preoperative C-reactive protein-to-lymphocyte ratio (7.51 vs. 24.49: p = 0.039), intraoperative bleeding (105 vs. 581 ml: p = 0.008), number of patients with major hepatectomy (4/45 vs. 3/8: p = 0.028), and number of patients with central venous oxygen saturation fluctuation ≥ 10% (11/45 vs. 6/8; p = 0.010). Central venous oxygen saturation fluctuation ≥ 10% (odds ratio: 9.53, p = 0.016) was the only independent predictor of elevated CCI.
Conclusions
Central venous oxygen saturation fluctuation during hepatectomy is a predictor of postoperative complications. Anesthetic management based on intraoperative dynamic monitoring and suppression of central venous oxygen saturation fluctuation may be effective measures to prevent postoperative complications.
Publisher
Research Square Platform LLC
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