LncRNAs Involved in the Regulation of Vascular Smooth Muscle Cell Proliferation and Migration in Atherosclerosis

Abstract

Abstract Atherosclerosis (AS) is a major cause of coronary artery disease, cerebral infarction,and peripheral vascular disease.Vascular smooth muscle cells（VSMCs）are oneof the major cell types in the vessel wall, and the abnormal proliferation and migration functions of VSMCs are critical in the process and stability of atherosclerotic plaque formation.In recently, an increasing number of studies have demonstrated that LncRNAs play an important role in the development of atherosclerotic disease. The purpose of thispaper is to summarize the LncRNAs involved in regulating the proliferation and migration of VSMCs in atherosclerosis, and to provide a scientific basis for the prevention and treatment of atherosclerosis.