Study on the Correlation Between the Expression of Cd68 and Cd25 and the Degree of Lesion in Granulomatous Mastitis

Abstract

Abstract Objective Study on the correlation between the expression of CD68 and CD25 and the degree of lesion in granulomatous mastitis. Material and methods 50 female patients with Graves' disease underwent mammary and thyroid gland surgeries during the study period. Post-surgery pathology analyses confirmed their diagnoses, and all patients were married, aged between 26 to 50 years, without signs of pregnancy or lactation. The ailment duration averaged at 2.5 months. Results Both Groups A and B expressed these cells positively, without a significant difference. However, Group C showed a lack of positive expression that differs significantly from Groups A and B. In Group A, CD68 and IgG expression levels were compared across different stages of the disease course in Table 3. The statistical analysis revealed no differences between these indicators (P > 0.05). Yet it highlighted a substantially higher level of CD25 expression in Group A between 15 days to 9 weeks when compared to those observed be low 15 days (P < 0.05). After ninety or more days had elapsed, however, there was no statistically significant difference observed with a p-value greater than 0.05. For Group B, No statistically significant differences were detected among the four indicators at various stages during the disease's development (P > 0.05). CD68, CD25, and IgG expression remained consistently high for a lesion size above or below 4 cm within group A. However, no significant variations were noticed as the p-value exceeded > 0.05. Conclusions GLM and PCM are diseases related to the immune system with different pathogenesis involving various immune cells and cellular elements. M2 macrophages play a crucial role in both GLM and PCM progression by promoting tumorigenesis. Inverted nipples can help distinguish between IgG4-related and non-IgG4-related GLM.