Evaluation of the effect of topical calcipotriol versus platelet-rich plasma versus a combination of both on patients with Alopecia Areata

Author:

Ali Mahmoud Ahmed Ali1,Taieb Moustafa Adam El Taieb El1,Younis Ali Mohamed Younis1,Ibrahim Hassan Mohamed Ibrahim2,Abdellatif Mohamed Amer Ahmed Abdellatif1,Ahmed Nour Mohammed Ahmed1,Ahmed Faten Othman Ahmed1,Hegazy Eisa Mohamed Hegazy2

Affiliation:

1. Aswan University

2. South Valley University

Abstract

Abstract Background: Alopecia areata (AA) is considered to be an autoimmune disease that has different treatment modalities. Topical vitamin D analog and PRP are recognized as effective therapies for AA. The aim of the study was a compare the effect of topical vitamin D analog (calcipotriol), intra-lesion PRP, and a combination of both on AA patients. Patients and methods: In this double-blinded randomized clinical trial study, a total of 39 cases (patients with AA) were divided into 3 groups: Group I (n = 13): cases received topical Vit D3 analog (calcipotriol) 0.005% twice daily for 3 months with follow up. Group II (n = 13): cases received PRP intra-lesion injection for 6 consecutive sessions 2 weeks apart. Combined Group III (n = 13):cases received both treatments. Clinical evaluation by SALT score (severity alopecia tool) and dermoscopic examination were performed before and after treatment. Study registration at clinicaltrial.com was done, approval number: NCT05954104. Date of registration: 23/6/2023. Results: In this study, there was a significant decrease in the mean SALT score for the three groups (p<0.001). The absolute reduction in G-I (calcipotriol) was 3.73 points, in G-II (PRP), was 6.87 points, and in G-III(combined) was 18.98 points This reduction was significant (p<0.001) more evident in G-III followed by G-II and then G-I. There was a significant reduction in Dermoscopic findings after treatment in the three groups. Conclusion: Significant reductions in SALT levels were observed across all three groups, with the combination of calcipotriol and PRP being particularly noteworthy. Significant reductions in dermoscopic symptoms were observed following treatment.

Publisher

Research Square Platform LLC

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