Building National Patient Registries in Mexico: Insights from the MexOMICS Consortium.

Abstract

Abstract OBJECTIVE To introduce MexOMICS, a Mexican Consortium focused on establishing electronic databases to collect, cross-reference, and share health-related and omics data on the Mexican population. METHODS The Mexican Twin Registry (TwinsMX), Mexican Lupus Registry (LupusRGMX) and the Mexican Parkinson’s Research Network (Mex-PD) were designed and implemented using Research Electronic Data Capture web-based application. Registries were compiled through voluntary participation and on-site engagement with medical specialists. In some instances, DNA samples and Magnetic Resonance Imaging images were also acquired. RESULTS Since 2019, the MexOMICS Consortium has successfully established three electronic-based registries: TwinsMX (n = 2915), LupusRGMX (n = 1761) and Mex-PD (n = 750). In addition to sociodemographic, psychosocial, and clinical data, MexOMICS has collected samples for genetic determinations across the three registries. Cognitive function assessments, conducted using the Montreal Cognitive Assessment, have been administered to a subsample of 376 Mex-PD participants. Furthermore, a subset of 267 twins underwent measurements of structural, functional, and spectroscopy brain images; comparable evaluations are projected for LupusRGMX and Mex-PD. CONCLUSIONS The MexOMICS registries offer a valuable repository of information concerning the potential interplay of genetic and environmental factors in health conditions among the Mexican population.