Affiliation:
1. Decheng hospital of Quanzhou/Affiliated of Huaqiao University
Abstract
Abstract
Objective: To construct a non-invasive diagnostic nomogram for chronic hepatitis B(CHB)- related early cirrhosis.
Methods 72 patients with CHB were enrolled in a prospective study, and divided into S4 stage of liver cirrhosis and S0-S3 stage of non-liver cirrhosis according to pathological findings. Binary logistic regression analysis was performed to identify independent predictors, and a diagnostic nomogram was constructed for CHB-related early cirrhosis. It was validated and calibrated by bootstrap self-extraction.
Results Binary logistic regression analysis showed that age, right hepatic vein diameter, presence or absence of nodules, and echogenicity grade of liver parenchyma were identified as independent risk factors. The AUC value of the diagnostic nomogram was 0.955, and the calibration curve fitted well with the ideal curve. Decision curve analysis showed that the net benefit of the nomogram was significant.
Conclusion The non-invasive diagnostic nomogram can achieve accurate diagnosis of CHB-related early cirrhosis, which may facilitate clinical management.
Publisher
Research Square Platform LLC