A Bidirectional Mendelian Randomization Study Revealed Genetic Evidence of Breast Cancer as a Risk Factor for Meningioma

Abstract

Abstract Background Although preceding observational research mentioned a potential connection between meningioma and breast cancer, verifying an unambiguous causal relationship has turned out problematic. Aiming to determine if breast cancer and the risk of meningioma intersect, we utilized a bidirectional two-sample Mendelian randomization (MR) analysis in this study. Besides, we investigated the influence of various estrogen receptor (ER) phenotypes on that association. Methods Breast cancer data from the Breast Cancer Association Consortium (BCAC) coupled with meningioma data from the FinnGen cohort were adopted in our investigation. Total participants of European descent were divided into four groups: 228,951 individuals (122,977 cases of breast cancer and 105,974 controls), 175,475 individuals (69,501 cases of ER-positive breast cancer and 105,974 controls), 127,442 individuals (21,468 cases of ER-negative breast cancer and 105,974 controls), and 287,614 individuals (1.237 cases of meningioma and 286,377 controls). The MR research, which utilized the power of the inverse variance weighting (IVW), weighted median (WM), and MR-Egger means, used tightly opted instrumental SNPs that were profoundly connected with exposure. Results According to the results of our forward MR study, there was a significant causal correlation between total breast cancer on meningioma (MR-Egger: OR = 1.4, 95% CI = 1.05–1.90, P = 0.022; WM: OR = 1.3, 95% CI = 1.02–1.50, P = 0.0248; IVW: OR = 1.2, 95% CI = 1.05–1.4, P = 0.0075). Furthermore, there was a probable causative relationship among ER-positive (ER+) breast cancer on meningioma (IVW: OR = 1.20, 95% CI: 1.03–1.30, P = 0.014), whereas no apparent connection between ER-negative breast cancer on meningioma emerged. Meningioma had little impact on the risk of breast cancer and breast cancer with different ER states, as shown to the inverse MR analysis drawing on the IVW, MR-Egger, and WM tests. Conclusion Following what comes of our forward MR investigation, there existed an unambiguous connection between the breast cancer in the population of European descent on meningioma. Likewise, we uncovered a potential combination referring to a causative relationship among ER + breast cancer on meningioma. However, there was no confirmation that suffering ER-breast cancer increases the possibility to grow meningioma. Furthermore, there was no causal relationship between overall breast cancer and breast cancer with different ER status on meningioma by our reverse MR examination.