Affiliation:
1. West China Hospital of Sichuan University
2. The First Affiliated Hospital of China Medical University
Abstract
Abstract
Objectives Non-steroidal anti-inflammatory drugs (NSAIDs) are currently the most common anti-inflammatory and analgesic drugs. Some clinical studies have reported that NSAIDs increase the incidence of several cardiovascular diseases (CVDs). However, a solid causal association has not been demonstrated. In this Mendelian randomization (MR) study, we investigated the causal association of NSAIDs use with the risk of CVDs.Methods A two-sample MR was utilized to determine whether there is a causal relationship between NSAIDs use and the risk of CVDs. Single-nucleotide polymorphisms(SNPs)associated with NSAIDs indices were used as instrumental variables to estimate the associations with the risk of CVDs. The dataset was obtained from genome-wide association studies (GWAS). Estimation of the causal effect was mainly performed using the random effects inverse-variance weighted method (IVW). Furthermore, Cochran’s Q test, MR-Egger intercept tests, MR-PRESSO, leave-one-out analyses, and funnel plot were used in the sensitivity analysis.Results NSAIDs use increase causally the risks of coronary heart disease [CHD; odds ratio(OR) = 1.005, 95% confidence interval(CI): 1.002–1.007, P < 0.05], heart failure(HF; OR = 1.091; 95% CI, 1.027–1.160; P < 0.05), atrial fibrillation(AF; OR = 1.087; 95% CI, 1.034–1.142; P < 0.05) with multiplicative random-effects IVW MR analysis. However, there was no suggestive evidence of a causal association between NSAIDs use and myocardial infarction (MI; OR = 1.001; 95% CI, 0.999–1.003; P = 0.23), or hypertension(OR = 1.001; 95% CI, 0.995–1.007; P = 0.72). The main results are kept stable in the sensitivity analysis.Conclusion This MR study provided support for a causal association of NSAIDs use with CHD, HF, and AF. However, it did not support an association of genetically predicted NSAIDs use on MI, and hypertension.
Publisher
Research Square Platform LLC