The Relationship Between Reproductive Hormones with bone mineral density and bone mineral content in a rapidly aging population

Abstract

Abstract Reproductive Hormones have the potential to affect Bone metabolism. Nevertheless, the correlation between reproductive hormones and levels of bone mineral density (BMD) and bone mineral content (BMC) in females is still inconclusive. The objective of our research was to examine how reproductive hormones affect bone metabolism in a population that is aging quickly. Methods: A cross-sectional study of 39,165 participants in the National Health and Nutrition Examination Survey (NHANES) 2011-2018 was conducted. The researchers conducted both multivariable linear regression modeling and propensity-score matching (PSM). Results: For analysis, a total of 4415 women who were 20 years old or older were included. In every multivariable linear regression model, BMD and BMC levels were found to have a negative correlation with menopausal status. Consistent results were also obtained after conducting PSM with 114 cases in each group. Conclusion: It was discovered that BMD and BMC levels were significantly lower in postmenopausal women in comparison to premenopausal women. Examining the correlation between reproductive endocrinology and bone mineral density is crucial for advancing clinical research and developing secure and efficient treatments for osteoporosis in a swiftly aging society.