Abstract
Abstract
Pre- and peri-natal complications represent well-known risk factors for the future development of psychiatric disorders. Such influence might become manifested during childhood and adolescence, as key periods for brain and behavioral changes. Internalizing and externalizing behaviors in adolescence have been associated with the risk of psychiatric onset later in life. Both brain morphology and behavior seem to be affected by obstetric complications, but a clear link between these three aspects is missing. Here, we aimed at analyzing the association between pre- and peri-natal complications, behavioral issues, and brain volumes in a group of children and adolescents. Eighty-two adolescents with emotional-behavioral problems underwent clinical and 3T brain magnetic resonance imaging (MRI) assessments. The former included information on behavior, through the Child Behavior Checklist/6–18 (CBCL), and on the occurrence of obstetric complications. The relationships between clinical and gray matter volume (GMV) measures were investigated through multiple generalized linear models and mediation models. We found a mutual link between prenatal complications, GMV alterations in the frontal gyrus, and withdrawn problems. Specifically, complications during pregnancy were associated with higher withdrawn scores and GMV reductions in the right superior frontal lobe and anterior cingulate cortex. Finally, a mediation effect of these GMV measures on the association between prenatal infections and the withdrawn dimension was identified. Our findings suggest a key role of obstetric complications in affecting brain structure and behavior. For the first time, we showed a mediator role of frontal GMV in the relationship between prenatal complications and internalizing symptoms.
Publisher
Research Square Platform LLC
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