The prognostic value of VISTA combined with imaging in pancreatic cancer patients

Abstract

Abstract Pancreatic ductal carcinoma (PDAC) is a malignant tumor of the digestive tract characterized by a gradual onset, rapid progression and poor prognosis. VISTA is a newly discovered immune checkpoint belonging to the B7 family of PD-1 and PD-L1. In this study, VISTA expression in tumor tissues was significantly higher than that in para-cancer tissues. It may also be associated with PDAC’s tumor immunosuppressive microenvironment. Furthermore, the best prognosis involved pancreatic cancer patients with high VISTA expression alongside a more uniform CT density. In addition, through immunohistochemistry, CCK-8 and EDU experiments, it was found that PTBP1 improved the immune infiltration of PDAC by regulating the expression of VISTA and promoting the expression of IFN-γ, TNF-α and other cytokines that delay the progression of tumors.