Synthesis of new polymeric composite materials derived from 2,2- (1,6-dioxohexane-1,6-diyl) dihydrazinecarbothioamide

Abstract

In the present study, synthesis and characterization of new polymeric nanocomposites. First, the compound [C₁] was formed from the reaction of one mole of dimethyl adipate with two moles of thiosemicarbazide in the ethanol absolute, then compound [C₁] was reacted with sodium hydroxide to yield compounds [C₂]. Compound [C₃] was synthesized by reaction of hydrazine hydrate with compound [C₂]. Compound [C₄] was synthetic from Maleic anhydride and compound [C₃]. Compound [C₄] reacted with ammonium per sulfate as an initiator to produce polymer [C₅], and then this polymer was blended with nano: ZnNPs, AgNPs, SiNPs, or IONPs by using a hotplate stirrer for 3 hours to produce nanocomposites [C₆-C₉]. The synthesized compounds were identified via spectral analysis techniques, including FTIR, 1H-NMR, and Field Emission Scanning Electron Microscope (FESEM). In addition, the thermal properties of TGA and DSC were studied. Molecular docking is studied, where operations are used to predict the binding status of compounds with the enzyme and to calculate the free energy (ΔG) of the compounds prepared. Finally, study biological activities screened via two types of bacteria (Bacillus cereus and Escherichia coli) and anti-cancer activity against HepG2 (human liver cancer cell line) and compare with the normal cell line WRL68 (normal liver cell line) of polymers and nanocomposites.