Affiliation:
1. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University
2. Department of General Medicine, Chongqing University Cancer Hospital
Abstract
Abstract
Purpose
To assess characteristics and prognostic factors among 18–40-year-old patients with lung cancer.
Methods
A retrospective analysis was performed using clinical data of 18–40-year-old patients diagnosed with primary lung cancer in the Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of the First Affiliated Hospital of Chongqing Medical University from 1 January 2015 to 1 January 2021. The patients’ characteristics and prognostic risk factors were analysed.
Results
This study included 284 patients (74 males and 210 females). Their median age was 36 years. In total, 77.11% of patients were asymptomatic at initial diagnosis. Moreover, 14.08%, 3.87% and 10.21% of patients had a smoking history, personal tumour history and family tumour history, respectively. Furthermore, 59.86% of the lesions were located on the right side, 58.10% were located in the upper lobe, 88.03% were sized ≤ 3 cm, 93.31% were adenocarcinomas, 84.51% were TNM stage 0-I and 90.85% required surgical treatment. Significant differences in smoking history, cough and expectoration, tumour density, tumour size, pathological type, disease stage and treatment modalities were noted between men and women. Multivariate analysis revealed that smoking history, disease stage, surgical treatment and targeted therapy were independent prognostic factors for overall survival.
Conclusion
The onset of lung cancer in 18–40-year-old people was insidious, and the symptoms were atypical, mainly in patients with early adenocarcinoma. Surgical treatment and targeted therapy were factors improving prognosis. Early diagnosis and treatment are thus crucial for improving the prognosis of young patients with lung cancer.
Publisher
Research Square Platform LLC
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