Identification of FKBP1A associated DC cell infiltration as malignant predictor to prognosis in Glioblastoma

Abstract

Abstract Purpose: FKBP1A is a member of the immunophilin protein family, which participates in basic cellular processes involving cell proliferation and immunity, especially interacting with rapamycin drug and mTOR protein. However, the relation between FKBP1A and clinical characteristics in glioblastoma (GBM)patients remains to be explored. Methods HPA, Prognoscan and GEPIA2 databases were used for data mining and analyzing FKBP1A, its co-expressed genes and dendritic cell (DC) related markers. TIMER2.0 database was used for analyzing the correlation and prognosis of FKBP1A and DC cells infiltration level in GBM. Results For the first time, we found that up-regulated FKBP1A expression and its co-expressed genes RPN2, DDOST and ITGB1 were correlated with GBM patients’ worse survival. Then, the oncogenic gene FKBP1A correlated with abundant infiltration of DC cell in GBM, the increase of DC marker NRP1 expression was also mined to be significantly correlated with worse survival in GBM. FKBP1A might play a role in the biological activity of protein N-linked glycosylation among GBM tumor microenvironment. Conclusions These findings infer that FKBP1A and its associated DC cell infiltration are significantly potential novel malignant prognostic indicators for GBM.