Affiliation:
1. Tianjin Medical University General Hospital
2. 2nd Hospital of Shandong University
3. Qilu Hospital of Shandong University
4. The Second Hospital of Hebei Medical University, Hebei Medical University
Abstract
Abstract
Background: Hirschsprung’s disease is characterized by the congenital absence of ganglion cells in the submucosal and myenteric plexuses of the intestine typically diagnosed in infancy. Here, we aimed to investigate the clinical effect of Soave’s operation on Adult Hirschsprung disease.
Methods: 21 patients aged from 21 to 35 years old with Hirschsprung’s Disease were studied. All cases were treated with Soave’s pull-through operation (total colectomy with ileoanal anastomosis). Clinical data of preoperative, postoperative complications and recovery condition after operation were recorded.
Results: All cases were treated with Soave’s operation successfully and followed up for 1-4 years. No patients suffered from serious complications, such as obstructive complication, anastomotic leakage, perianal excoriation, soiling, fecal incontinence, urination disorders and sexual disorder in male patients. There were 2 cases who had postoperative enterocolitis with hyperthermia (38-39°C) but recovered after being treated with antibiotics and retention enema for 5-7 days. After Soave’s operation, the defecation frequency of the Adult Hirschsprung disease was 2-3 times a day, and the defecation time was 6.4±4.31 minutes, which was significantly improved compared with that before the operation (preoperative interval days of defecation: 5.82±6.32 days; preoperative average defecation time: 20.4±11.3 minutes, P<0.05).
Conclusions: The above data prove that Soave’s operation appears to be an effective and safe procedure for Adult Hirschsprung disease, through which not only reduces postoperativecomplications, but also remains sexual function and defecate function.
Publisher
Research Square Platform LLC