Genomic landscape of diffuse glioma revealed by whole genome sequencing-Reference-Cited by-同舟云学术

Genomic landscape of diffuse glioma revealed by whole genome sequencing

Published:2023-11-03 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Kinnersley Ben¹^ORCID,Jung Josephine²^ORCID,Cornish Alex³^ORCID,Chubb Daniel³,Laxton Ross⁴,Frangou Anna⁵,Gruber Andreas⁶^ORCID,Sud Amit⁷^ORCID,Caravagna Giulio³,Sottoriva Andrea⁷,Wedge David⁸^ORCID,Booth Thomas²,Al-Sarraj Safa⁹,Lawrence Sam⁷,Albanese Erminia¹⁰,Anichini Guilio¹¹,Baxter David¹²,Boukas Alexandros¹³,Chowdhury Yasir¹⁴,D'Urso Pietro¹⁵,Corns Robert¹⁶,Dapaah Andrew¹⁷,Edlmann Ellie¹⁸,Greenway Fay¹⁹,Grundy Paul²⁰,Hill Ciaran²¹,Jenkinson Michael²²,Krishna Sandhya²³,Smith Stuart¹⁷,Manivannan Susruta²⁰,Martin Andrew²⁴,Matloob Samir²⁵,Mukherjee Soumya²⁶,O'Neill Kevin¹¹,Plaha Puneet¹³,Pollock Jonathan²⁵,Price Stephen²⁷^ORCID,Rominiyi Ola²⁸,Sachdev Bobby¹⁰,Saeed Fozia¹⁶,Sinha Saurabh²⁸,Thorne Lewis²¹^ORCID,Ughratdar Ismail¹⁴,Whitfield Peter¹⁸,Youshani Amir¹⁵,Bulbeck Helen²⁹,Arumugam Prabhu³⁰,Houlston Richard⁷^ORCID,Ashkan Keyoumars⁴

Affiliation:

1. UCL Cancer Institute

2. King's College Hospital NHS Foundation Trust

3. Institute of Cancer Research

4. King’s College Hospital NHS Foundation Trust

5. Big Data Institute

6. University of Konstanz

7. The Institute of Cancer Research

8. University of Manchester

9. King's College London

10. Royal Stoke University Hospital

11. Imperial College Healthcare NHS Trust

12. Royal National Orthopaedic Hospital

13. John Radcliffe Hospital

14. Queen Elizabeth Hospital Birmingham

15. Manchester Royal Infirmary

16. Leeds General Infirmary

17. Queen’s Medical Centre NHS Trust

18. University Hospitals Plymouth NHS Trust

19. St. George’s University Hospitals NHS Foundation Trust

20. University Hospital Southampton

21. National Hospital for Neurology and Neurosurgery Queen Square

22. Department of Neurosurgery, The Walton Centre, Liverpool

23. The Walton Centre NHS Foundation Trust

24. St George's Hospital

25. Queen’s Hospital Romford

26. Addenbrookes Hospital

27. University of Cambridge

28. Sheffield Teaching Hospitals NHS Foundation Trust

29. Brainstrust

30. Genomics England

Abstract

Abstract Diffuse gliomas are the commonest malignant primary brain tumour in adults. Herein, we present the most comprehensive analysis of the genomic landscape of adult glioma to date, by whole genome sequencing of 403 tumours. We identify an extended catalogue of recurrent coding and non-coding genetic mutations that represents a source for future studies and provides the most complete high-resolution map of structural variants, copy number changes and global genome features including telomere length, mutational signatures and genomic complexity. Finally, we relate these to clinical outcome. As well as identifying new DNA level drug targets for treatment of glioma findings offer the prospect of improving treatment allocation with targeted therapies.

Publisher

Research Square Platform LLC

Reference53 articles.

1. Epidemiology of glial and non-glial brain tumours in Europe;Crocetti E;Eur J Cancer,2012

2. Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium;Bondy ML;Cancer,2008

3. Improved survival time trends for glioblastoma using the SEER 17 population-based registries;Koshy M;J Neurooncol,2012

4. Brennan, C.W. et al. The somatic genomic landscape of glioblastoma. Cell 155, 462 – 77 (2013).

5. Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors;Eckel-Passow JE;N Engl J Med,2015