Risk factor analysis of hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation in children with severe thalassemia

Abstract

Abstract Purpose To explore the possible risk factors for hemorrhagic cystitis (HC).Methods We retrospectively analyzed 152 cases of severe thalassemia in allogeneic hematopoietic stem cell transplantation from January 2011 to December 2021 in our hospital. Evaluating incidence rate、occurrence time and duration of HC. Analysis of age,the degree of blood type compatibility, HLA matching configuration,the amount of CD34 + cells, Cyclosporin A concentration, Whether complications such as infection, GvHD and other complications were combined, Classification of risk of thalassemia (pretransplant assessment), different types of transplantation, in which that degree of the iron overload before and aft transplantation is related to the occurrence of HC.Results The results showed that the incidence of HC after transplantation was 27.63%.The median time for the occurrence of HC is 21d, and the duration is 11d.Only one cases were early onset HC (EOHC), and the other 41 were delayed HC (LOHC).The incidence rate of 4 years of age or older children with HC (33.70%) is higher than the age < 4 years old children (16.67%).The difference was statistically significant (P = 0.021).Conclusion Iron overload may have an impact on the occurrence of HC.As the level of SF increased, the incidence of HC increased significantly.iron overload may have an effect on HC occurrence.With the increase of SF, the incidence of HC increased significantly, especially when SF was greater than 7969.84.Children younger than 4 years of age were more likely to deelop HC after transplantation.