The relationship between human papillomavirus genotype distribution and age and the association with high-grade squamous intraepithelial lesions of the cervix or cervical cancer in Jilin Province, China

Abstract

Abstract Human papillomavirus (HPV) infection is related to the occurrence of cervical cancer. We enrolled 21,282 individuals, including 634 males and 20,648 females, in Jilin Province, China, from October 2017 to September 2019. Significant variations were observed in the prevalence of HPV types 16, 18, 31, 33, 52, 56, 58, 59, 66, 53, 6, and 11 across different age groups (P < 0.05). The occurrence of HPV infection was considerably greater among females than among males. Additionally, a noteworthy association was found between HPV16, 18, 33, and 58 infections and the presence of high-grade squamous intraepithelial lesions or cervical cancer in females. This relationship exhibited a U-shaped relationship with age. Our study might play a role in guiding women of different ages to get tested for HPV infections and determine the right HPV vaccine in relation to a woman's age.