Affiliation:
1. Hunan University of Traditional Chinese Medicine
2. First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
3. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Abstract
Abstract
Background
Reports suggest an association between periodontitis and oral cancer. Therefore, this study used a Mendelian randomisation analysis to investigate whether a causal relationship exists between periodontitis and oral cancer and whether periodontitis is a reliable early indicator of oral cancer.
Methods
Publicly available genome-wide association study data were used to perform a two-sample, two-way Mendelian randomisation (MR) analysis primarily via inverse variance weighting (IVW). Complementary methods were used to detect and correct the effects of horizontal polytropy.
Results
Acute periodontitis (IVW [odds ratio (OR) = 0.999, 95% confidence interval (CI) = 0.999–1.000, P = 0.972]; MR-Egger [OR = 1.000, 95% CI = 0.999–1.000, P = 0.843]; and weighted median [OR = 1.000, 95%CI = 0.999–1.000, P = 0.947]) and chronic periodontitis (IVW [OR = 0.999, 95% CI = 0.999 − 1.000, P = 0.725; MR-Egger [OR = 1.000, 95% CI = 0.998–1.000, P = 0.245); and weighted median [OR = 1.000, 95% CI = 0.999–1.000, P = 0.834]) did not affect oral cancer.
Conclusions
Our MR analysis did not support a causal relationship between periodontitis and oral cancer, providing a clear reference for clinicians.
Publisher
Research Square Platform LLC
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