Association of Klotho with coronary artery disease in subjects with type 2 diabetes mellitus and preserved kidney function: a case-control study.

Abstract

Abstract Aims A significant reduction in circulating Klotho levels is observed in subjects with type 2 diabetes mellitus (T2DM). In this work, we examined the relationship between Klotho levels and coronary artery disease (CAD) burden in subjects with T2DM and preserved kidney function. Methods Cross-sectional case-control study involving 133 subjects with T2DM and 200 age-, sex- and CAD incidence-matched, non-diabetic patients undergoing nonemergency diagnostic coronary angiography. All of them non-albuminuric and with normal glomerular filtration rates. Concentrations of serum Klotho, fibroblast growth factor 23, and inflammatory markers were also measured. Results The Klotho concentration was lower in the group with DM2 although higher in the subgroup of subjects with DM2 and significant CAD (45.6%; P=0.02). Multiple regression analysis revealed that serum Klotho was positively related with SSI values exclusively in subjects with T2DM (adjusted R2=0.153, P<0.01). Logistic regression analysis showed that Klotho was positively associated with the presence of significant CAD in the group of T2DM patients (OR: 1.001; P=0.041). Conclusions Our data suggest that higher levels of circulating Klotho in subjects with T2DM and preserved kidney function are associated with significant CAD.