Acute Helicobacter pylori infection incidence and association with metabolic abnormalities in the general Chinese population: a retrospective study

Abstract

Abstract Objective: Helicobacter pylori (H. pylori) infection is common worldwide, and previous studies on the correlation between H. pylori infection and metabolic abnormalities have provided inconsistent conclusions. We assessed the incidence of acute H. pylori infection and its relationship with metabolic abnormalities in the general Chinese population. Methods: Participants attending the physical examination underwent a carbon-13 urea breath test (13C-UBT). For individuals, the following data were collected: age, sex, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), total protein, albumin (ALB), globulin (GLB), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), alanine transaminase (ALT), glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), urea nitrogen, creatinine, uric acid, fasting plasma glucose (FPG), and homocysteine. Results: A total of 29154 participants were enrolled. The prevalence of acute H. pylori infection was 29.79% (8684/29154). Spearson correlation analysis showed that gender, BMI, ALB, GLB, TBIL, DBIL, IBIL, and FPG were closely related to H. pylori infection. Multivariate logistic regression analysis with stepwise subset selection further identified sex, BMI, ALB concentration, GLB concentration, DBIL concentration, and FPG as independent risk factors for acute H. pylori infection. Conclusion: Our results indicated that acute H. pylori infection might have a significant impact on metabolic abnormalities, which should be further confirmed.