Antioxidant-Rich Diets Associated with Reduced Mortality Risks: Findings from NHANES Cohort

Author:

Li Yuguang1,Chen Xinqiao1,Li Qiguang1,Wang Yao1,Zhao Yixin1,Zhang Rong1,Shi Hanping2,Liu Xiangliang1,Cui Jiuwei1,Li Wei1

Affiliation:

1. The First Hospital of Jilin University

2. Capital Medical University

Abstract

AbstractBackground The composite dietary antioxidant index (CDAI) reflects an individual's dietary intake of antioxidants. This study aimed to investigate the association between CDAI and mortality outcomes. Methods Data from 18,046 adults aged 18–80 years were analyzed from the US NHANES 2011–2018. CDAI was calculated from dietary vitamins A, C, E and minerals selenium, magnesium and zinc. All-cause and cancer mortality were ascertained through 2019. Cox models evaluated CDAI-mortality associations. Results Increasing CDAI quartiles were associated with decreasing all-cause mortality risk (high vs low Q4 vs Q1 HR 0.699, 95% CI 0.579–0.844, p < 0.001). A similar trend was observed for cancer mortality (Q4 vs Q1 HR 0.727, 95% CI 0.507–1.044, p = 0.084). Stronger associations were found in males. Conclusions Higher CDAI, reflecting greater dietary antioxidant intake, was associated with lower all-cause and cancer mortality. CDAI may be a useful tool for assessing antioxidant status and health outcomes. Further research is warranted on potential gender differences.

Publisher

Research Square Platform LLC

Reference40 articles.

1. Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies;Wang X;Br J Nutr,2014

2. Effects and safety of periconceptional oral folate supplementation for preventing birth defects;De-Regil LM;Cochrane Database Syst Rev,2015

3. Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal;Salzano S;Proc Natl Acad Sci U S A,2014

4. Effects of antioxidant supplementation on the aging process;Fusco D;Clin Interv Aging,2007

5. Modulation of oxidative stress as an anticancer strategy;Gorrini C;Nat Rev Drug Discov,2013

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