DEPTOR levels in patients with mycosis fungoides

Author:

Çerman Aslı Aksu1,Bulat Ceylan1,Çetinkaya Pınar Özdemir1,Kurt Birgül Özkesici1,Odabaşı Merve Sena2,Altunay İlknur1

Affiliation:

1. Health Science University, Şişli Hamidiye Etfal Training and Research Hospital, Dermatology Department

2. Health Science University, Şişli Hamidiye Etfal Training and Research Hospital, Biochemistry Department

Abstract

Abstract The mammalian target of rapamycin (mTOR) signaling pathway is upregulated in the pathogenesis of many cancers, including cutaneous T cell lymphoma. DEPTOR is an mTOR binding protein and endogenous mTOR inhibitor. However, the significance of DEPTOR in the development of mycosis fungoides (MF) is not known. This study aimed to investigate the possible role of DEPTOR in the pathogenesis of MF. Forty patients with MF and 40 healthy controls were included in the study. Serum fasting DEPTOR levels of the study groups were examined by enzyme-linked immunosorbent assay. The mean serum DEPTOR levels were significantly lower in patients with MF than controls (p<0.05). In conclusion, DEPTOR is possibly a novel tumor suppressor protein in MF. DEPTOR reactivation may be a potential therapeutic approach for patients with MF.

Publisher

Research Square Platform LLC

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