Affiliation:
1. National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC)
2. Guangxi Center for Disease Control and Prevention
3. University of Tennessee Health Science Center
Abstract
Abstract
Background
Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors associated with HIV treatment outcomes.
Methods
This cross-sectional study was conducted in Guangxi, China, between July and August 2021. HIV-infected children answered questionnaires about BEDs, physical health, social support, and whether they have missed doses in the past month. BEDs were assessed using the Chinese version of the self-reported Strengths and Difficulties Questionnaire (SDQ-C). Univariate and multivariate logistic regression models were used to identify factors that were associated with missed doses in the past month and virological failure.
Results
The study sample was 325 HIV-infected children. HIV-infected children had a higher proportion of abnormal scores on SDQ-C total difficulties compared to their peers in the general population (16.9 vs 10.0%; P = 0.002). An abnormal SDQ-C total difficulties score (AOR = 2.06, 95%CI: 1.10–3.88) and infrequency of receiving assistance and support from parents over the past 3 months (AOR = 1.85, 95%CI: 1.12–3.06) were significantly associated with missed doses in the past month. Between the ages of 14–17 years (AOR = 2.66, 95% CI: 1.37–5.16), female (AOR = 2.21, 95% CI: 1.20–4.08), and suboptimal adherence (AOR = 2.45, 95% CI: 1.32–4.57) were significantly associated with virological failure.
Conclusions
Children’s mental health plays a role in HIV treatment outcomes. Psychological interventions should be promoted in pediatric HIV care clinics to improve children’s mental health status and HIV treatment outcomes.
Publisher
Research Square Platform LLC
Reference40 articles.
1. World Health Organization (WHO). Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. 2015. Available at: https://www.who.int/publications/i/item/9789241509565. Accessed 9 January 2023.
2. Joint United Nations Programme on HIV/AIDS (UNAIDS). Global HIV & AIDS statistics — Fact sheet. 2021. Available at: https://www.unaids.org/en/resources/fact-sheet. Accessed 9 January 2023.
3. National Center for AIDS & STD Control and Prevention, The Chinese Center for Disease Control and Prevention (CDC). Annals of Information on Comprehensive Prevention and Treatment for AIDS, STD and Hepatitis C. Beijing: National Center for AIDS & STD Control and Prevention; 2020. pp. 5–12.
4. Global estimates of viral suppression in children and adolescents and adults on antiretroviral therapy adjusted for missing viral load measurements: a multiregional, retrospective cohort study in 31 countries;Han WM;Lancet HIV,2021
5. Incidences and factors associated with viral suppression or rebound among HIV patients on combination antiretroviral therapy from three counties in Kenya;Maina EK;Int J Infect Dis,2020