Affiliation:
1. Sun Yat-sen University
Abstract
Abstract
Gastric cancer (GC) is one of the most common malignant tumors in the digestive tract. Liver metastasis is the most common mode of hematogenous metastasis. Patients with GC with liver metastasis (GCLM) progress rapidly and have a poor prognosis. Therefore, there is an urgent need for a method that can combine the patient's basic condition and tumor characteristics to predict the patient's prognosis. This study used the SEER database to explore the relevant risk factors for the prognosis of GCLM, and established a nomogram with good survival prediction ability, in order to facilitate personalized prognosis evaluation and follow-up strategy formulation for patients in clinical practice. We found that age, pathological grade, surgery, and chemotherapy are independent risk factors affecting the prognosis of GCLM. We established a nomogram for the prognosis of GCLM based on the four independent risk factors mentioned above, and conducted internal and external validation using the SEER database and the First Affiliated Hospital of Sun Yat-sen University database. The results showed that the nomogram has good predictive ability and can be used to assist clinical doctors in evaluating patient prognosis and formulating personalized follow-up strategies, while making corresponding personalized treatments as early as possible.
Publisher
Research Square Platform LLC
Reference75 articles.
1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [J];SUNG H;CA Cancer J Clin,2021
2. Hepatic resection for gastric cancer liver metastases: A systematic review and meta-analysis [J];PETRELLI F;Journal of surgical oncology,2015
3. Liver resections in metastatic gastric cancer [J];KERKAR S P, KEMP C D, AVITAL I;HPB: the official journal of the International Hepato Pancreato Biliary Association,2010
4. Patterns of initial recurrence in completely resected gastric adenocarcinoma [J];D'ANGELICA M;Annals of surgery,2004
5. Liver resection for metastatic gastric cancer [J];THELEN A;European journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,2008