Affiliation:
1. National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Children’s Hospital of Chongqing Medical University
2. Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University
Abstract
Abstract
Background
In clinical work, the BPD definition has not been clearly unified and standardized, which limits clinical progress. A BPD diagnostic screening standard that can effectively predict the prognosis, as well as standardize the clinical early diagnosis and treatment of BPD, is needed.
Methods
We conducted an ambispective cohort study to compare the effects of the three different definitions of BPD on clinical diagnosis and the predictive ability of prognosis (followed to 18–24 months corrected age).
Findings:
The diagnostic rate of BPD defined in 2001 was significantly higher than that created in 2018 or 2019 (P < 0.05), while the probability of adverse outcomes in infants with moderate and severe BPD diagnosed by the 2018 and 2019 definitions was significantly higher than those diagnosed by the 2001 definition (P < 0.05).
Interpretation:
The 2018 and 2019 diagnostic definitions are more accurate in predicting BPD-related adverse outcomes, especially respiratory outcomes. We suggest that for infants with BPD diagnosed via the 2001 definition, moderate and severe BPD should be screened again using the 2019 definition (which is easier to define than 2018), and early preventive intervention should be carried out.
Publisher
Research Square Platform LLC