Recurrence and prognosticators of recurrence in odontogenic keratocyst of the jaws.

Abstract

Abstract Introduction: The incidence of recurrence of OKC varied from 2.5%-62%. Studies have linked recurrence to treatment methods and also clinical and pathological features. The aim of this study was to evaluate the 5 year recurrence and the factors associated with recurrence in odontogenic keratocysts of the jaws.Methods: A retrospective review of records was done from the Institute’s Medical Records Directory from 2010-2021. The following data were obtained of the lesion; age at presentation, gender, site, subsite, radiographic presentation (locularity), radiographic borders, presence or absence of satellite cysts, inflammatory infiltrate, and treatment rendered presence or absence of cortical perforation and soft tissue extension and presence or absence of recurrence. Kaplan Meir estimator was used to evaluate recurrence rate and log rank test was used to compare the survival amongst groups. Cox regression analysis was used to evaluate the odds ratio to find out the possible factors influencing risk of recurrence. A p value of <0.05 was considered statistically significant at 95% confidence interval. Results: In our study cohort 44.44% had recurrence. Multilocular lesions, lesions with scalloped borders, presence of soft tissue extension and cortical perforation, presence of satellite cysts and inflammatory infiltrate and enucleation with peripheral ostectomy were significantly associated with recurrence. However; soft tissue extension, cortical perforation, enucleation with peripheral ostectomy and marsupialization followed by enucleation+ peripheral ostectomy were independent risk factors. Conclusion: There is still debate on the best treatment modality for the management of OKCs. More studies are required to quantify the results.