Real World Treatment Outcomes in Polypoidal Choroidal Vasculopathy in a Caucasian Population of British Ethnicity.

Abstract

Abstract Purpose To assess treatment response of Polypoidal choroidal vasculopathy (PCV) in a Caucasian population of British ethnicity with intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections alone and with a combination of anti-VEGF injections and photodynamic therapy (PDT). Setting/Venue Department of Ophthalmology, University Hospitals Southampton NHS Foundation Trust, United Kingdom. Methods Retrospective review of 95 Caucasian patients (see Table 1) in a single centre with diagnosis of PCV between 2013 and 2018 were included. Best corrected visual acuity (BCVA), central retinal thickness (CRT), indocyanine green angiography (ICGA) characteristics, numbers and type of treatment were analysed at baseline and at 1 year. Results One hundred and six eyes included from 95 patients received either anti-VEGF injections (n = 72, 71.3%) alone or combination therapy with anti-VEGF and PDT (n = 13, 12.9%). A third untreated group was also observed (n=16, 15.8%). Five eyes were excluded from the study due to structural retinal damage. Mean number of injections was 16.4 in the monotherapy group and 19.9 in the combination group. Both treatment groups showed improvement in BCVA (See Table 2) at 1 year and this was statistically significant in the monotherapy group with a mean gain of 8.3 letters (p<0.001). Mean CRT decreased (see Table 3) in all treatment groups at twelve months and this change was significant (p<0.01). In the observation group, vision and CRT remained stable. Conclusions This study demonstrates significant improvements in BCVA at one year in our Caucasian cohort of British ethnicity with PCV in the treatment group.