Affiliation:
1. IIT Bhilai: Indian Institute of Technology Bhilai
Abstract
Abstract
A method of drug delivery that could provide control over
medicine reaching the bloodstream for systemic circulation would be
of immense importance. This work presents a comparative study of
the temporal and spatial variation of drugs diffusing passively
through two separate routes of human skin, namely intercellular
(ICR) and sweat duct route (SDR). Analysis is carried out for two
age groups (young < 40 years and old > 60 years of age).
Governing equations based on Fick’s law for mass transfer has been
solved numerically using an in-house developed code. The code has
been validated thoroughly with numerical and experimental work from
literature. Each skin route is modeled into three compartments
sandwiched between donor and receiver compartment. To understand
the role of diffusion and partition coefficient on drug permeation,
four drugs, namely hydrocortisone, transcinnamic acid, caffeine,
and benzoic acid, are considered. Drug diffusion rate is found
greater through ICR as compared to SDR. Further, the amount of
drugs diffusing through both routes increases with age. Desirable
drug characteristic is inferred to be a lower value of partition
coefficient and a higher value of diffusion coefficient. This study
could lead to real-time assessment of medicines reaching the
bloodstream and beyond.
Publisher
Research Square Platform LLC
Cited by
1 articles.
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