In vitro and in vivo evaluation of alginate hydrogel-based wound dressing loaded with green chemistry cerium oxide nanoparticles

Abstract

Abstract Interactive wound dressings have shown promising results in promoting the wound healing process. In the present study, we tried to fabricate interactive/bioactive nanocomposite wound dressing with potent antioxidant properties. We fabricated cerium oxide nanoparticles using curcumin as the reducing and capping agent. SEM, EDX, DLS, Zetasizer, FTIR, and XRD were applied to characterize the green-synthesized cerium oxide nanoparticles. The synthesized nanoparticles were incorporated into alginate hydrogel and the microstructure, porosity, and swelling state of the fabricated wound dressing were evaluated. The characterizations revealed the physical and chemical properties of the green-synthesized cerium oxide nanoparticles and the incorporated alginate hydrogel-based wound dressing. The in vitro studies showed that the alginate hydrogel-based wound dressing exhibited acceptable antioxidant activities and were hemocompatible and biocompatible. The animal studies (rat full-thickness skin wound model) showed that the alginate hydrogel-based wound dressing were able to promote the wound healing process. The results indicated that the alginate hydrogel-based wound dressing can be applied as effective wound dressing/healing materials.