Affiliation:
1. Max Planck Institute for the Science of Light
2. FAU Erlangen-Nürnberg
3. ETH Zurich
Abstract
Abstract
Precise cell elimination within intricate cellular populations is hampered by issues arising from the multifaceted biological properties of cells and the expansive reactivity of chemical agents. Current platforms are often limited by their complexity, toxicity, and poor physical/chemical properties. Here, we integrate the spatio-temporal precision of light delivery and the structural versatility of bisacylphosphane oxides (BAPOs), establishing a universal strategy for on-demand, precise cellular ablation in vitro and in vivo.
Publisher
Research Square Platform LLC
Reference24 articles.
1. Small molecules in targeted cancer therapy: advances, challenges, and future perspectives;Zhong L;Signal Transduct Tar,2021
2. D. Cellular senescence in ageing: from mechanisms to therapeutic opportunities;Micco R;Nat Rev Mol Cell Bio,2021
3. A genetically encoded photosensitizer;Bulina ME;Nature Biotechnology,2006
4. A genetically targetable near-infrared photosensitizer;He J;Nature Methods,2016
5. Isacoff, E. Y., Kramer, R. H. & Trauner, D. (eds Peter Hegemann & Stephan Sigrist) 35–46 (De Gruyter, 2013).