Observational study on the application of remazolam toluenesulfonate and propofol in abortion

Abstract

Abstract Background Anesthetic effects of remazolam and propofol have never been compared in induced abortion. This study aimed to compare their safety and efficacy. Methods Sixty-two patients who underwent painless abortion in our hospital were randomly divided into two equal groups: remazolam tosylate(0.26 mg/kg; 1.3 ED50) + fentanyl ( 1 μg/kg) (RF group) or intravenous propofol(2 mg/kg) + fentanyl ( 1 μg/kg) (PF group). Additional rescue sedation with propofol ( 1 mg/kg) was administered based on body movement and operation duration. The heart rate (HR), mean arterial pressure (MAP), oxygen saturation, Narcotrend Index, Modified Observer’s Assessment of Alertness/Sedation (MOAA/S) score, awakening time, remedial sedation, and adverse reactions were compared between groups at eight time points:upon operating room entry (T0), 1 min post-fentanyl and post-remifentanil/propofol administration (T1,T2), upon initiation of the operation (T3), 3 and 5 min post-operation (T4,T5), at the end of operation (T6), and upon awakening (T7). Results Large circulatory fluctuations were observed in the PF group; the MAP decreased significantly, as did the HR at T0 compared with T4 (P<0.05). Based on the Narcotrend Index values assessed over time, both groups reached clinical sedation, with significantly lower values at T2, T3, and T4 than at T0 (P<0.05). The Narcotrend Index in the PF group was significantly lower than that in the RF group at T2, T3, and T4 (P<0.05). Within each group, the MOAA/S scores were significantly lower at T2 and T3 (P<0.05). Conclusion Remazolam tosylate is more efficacious and induces fewer adverse reactions than propofol in painless abortion.