Predictive value of end-tidal carbon monoxide concentration (ETCOc) within 48 hours after birth in neonatal hyperbilirubinemia caused by hemolysis.

Abstract

Abstract OBJECTIVES: To investigate the predictive value of end-tidal carbon monoxide concentration (ETCOc) within 48 hours after birth in neonatal hyperbilirubinemia caused by hemolysis. METHODS: A prospective study was conducted on hemolytic high-risk newborns. ETCOc within 24 hours (D1-ETCO) and between 24 to 48 hours after birth (D2-ETCO) were measured. They were divided into a normal group, a nonhemolytic hyperbilirubinemia (NHH) group, and a hemolytic group based on whether they had hyperbilirubinemia or hemolysis. RESULTS: The hemolytic group had the highest ETCOc values, followed by the NHH group, and the normal group. The AUC of D1-ETCO and D2-ETCO were 0.958 and 0.862. The sensitivity and specificity were 83.3%, 94.7%, 72.0%, and 96.0%, respectively. There was a linear correlation between D1-ETCO and total bilirubin /age at admission ratio and reticulocytes (r = 0.896 and 0.878, respectively). CONCLUSIONS: ETCOc within 48 hours can predict hyperbilirubinemia caused by hemolysis well.