Affiliation:
1. Mashhad University of Medical Sciences
2. Islamic Azad University, Damghan Branch
Abstract
Abstract
Background: Esophageal squamous cell carcinoma (ESCC) is one of the world's deadliest cancer diseases. Deregulation of developmental signaling pathways such as Wnt/β-catenin is frequently implicated in a wide range of human cancers. The present study was designed to analyze the expression of the Pygopus2 (PYGO2) protein, the main co-activator of the Wnt/β-catenin signaling pathway, in ESCC tissues and evaluate its probable correlation with clinic-pathological features of patients.
Materials and Methods: In this study, PYGO2 protein expression was assessed in tumors and margin normal tissues from 50 ESCC patients using immunohistochemistry (IHC) analysis.
Results: Significant PYGO2 overexpression was observed in %94 tumor cells. Interestingly, PYGO2 expression was significantly correlated with the depth of tumor invasion (p= 0.021). Considering the significant expression of PYGO2 protein in ESCC cells and its correlation with tumor invasion.
Conclusion: This protein may be used as a biomarker for diagnosis of invasive ESCC, as well as a putative therapeutic target to inhibit ESCC invasiveness.
Publisher
Research Square Platform LLC