Affiliation:
1. First Affiliated Hospital of Bengbu Medical College
Abstract
Abstract
Background
The present study mined key lncRNAs and their functions related to inflammation in type 2 diabetes by constructing a lncRNA-mRNA co-expression network based on bioinformatics technology to discover new markers or therapeutic targets.
Results
We finally obtained 12 genes, including A1BG-AS1, AC084125.4, RAMP2-AS1, FTX, DBH-AS1, LOXL1-AS1, LINC00893, LINC00894, PVT1, RUSC1-AS1, HCG25, and ATP1B3-AS1. RT-qPCR verified that A1BG-AS1, HCG25, and LOXL1-AS1 were upregulated in the HG + LPS-induced THP-1 cell model, and DBH-AS1 was downregulated in the HG + LPS-induced THP-1 cell model.
Conclusions
LncRNAs and mRNAs are extensively linked and form a co-expression network, and lncRNAs may influence the development of type 2 diabetes by regulating the corresponding mRNAs. The four key genes obtained may become biomarkers of inflammation in type 2 diabetes in the future.
Publisher
Research Square Platform LLC
Reference42 articles.
1. Anthropometric and adiposity indicators and risk of type 2 diabetes: systematic review and dose-response meta-analysis of cohort studies;Jayedi A;Bmj,2022
2. Identification of Potential Therapeutic Targets in the Liver of Pioglitazone-Treated Type 2 Diabetes Sprague-Dawley Rats via Expression Profile Chip and iTRAQ Assay;Lu ZX;J Diabetes Res,2018
3. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables;Ahlqvist E;The Lancet Diabetes & Endocrinology,2018
4. Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus;Huang L;Int J Endocrinol,2021
5. DiCorpo D, LeClair J, Cole JB, Sarnowski C, Ahmadizar F, Bielak LF, Blokstra A, Bottinger EP, Chaker L, Chen YI et al: Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 individuals Across 13 Cohorts. Diabetes Care 2022.
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