Affiliation:
1. Kaohsiung Chang Gung Memorial Hospital
Abstract
Abstract
Purpose
Inconsistent results have been noted for the difference in survival outcome between laparoscopic liver resection (LLR) and percutaneous radiofrequency ablation (pRFA) for single hepatocellular carcinoma (HCC) ≤ 3.0 cm in size. We aimed to clarify this issue.
Methods
From 2011 to 2021, 232 patients undergoing LLR and 507 patients undergoing pRFA for early-stage HCC with a single tumor of ≤ 3.0 cm were enrolled. The patients had Child–Pugh class A liver disease. Survival analysis with propensity score matching (PSM) was performed using the Kaplan − Meier method.
Results
Before PSM, LLR was associated with a significant survival benefit compared to pRFA (five-year overall survival [OS]: p = 0.034; five-year recurrence-free survival [RFS]: p < 0.001). Multivariate analysis showed that the pRFA vs LR comparison was not associated with five-year OS (p = 0.063); however, it was associated with inferior five-year RFS (p < 0.001). After PSM, five‐year OS did not differ significantly between the two groups (p = 0.184); however, LLR resulted in superior RFS compared to pRFA (p < 0.001).
Conclusion
LLR resulted in superior five-year RFS compared to pRFA in treating early-stage HCC with a single tumor ≤ 3.0 cm in size; however, five-year OS was not significantly different between LLR and pRFA.
Publisher
Research Square Platform LLC