Neurotoxicological effects of agrochemicals and their probable degradation by-products in Drosophila melanogaster

Author:

Ramalho Douglas Lisboa1,Silva Jadyellen Rondon1,Santos Maria Eduarda Monteiro Martins dos1,Soares Maria Eduarda Silva1,Jesus Andrielle Adelina Teodoro1,Alves Thiago Henrique Oliveira1,Brugnera Michelle Fernanda1,Moura Sidnei2,Souza Anderson Oliveira1

Affiliation:

1. Universidade Federal de Mato Grosso

2. University of Caxias Do Sul

Abstract

Abstract Photodegradation is a promising technique for remediating contaminated environmental matrices, demonstrating significant yield of transforming organic contaminants into carbon dioxide, water, and inorganic anions through degradation reactions that involve transient oxidizing species, mainly hydroxyl radicals generated by UV irradiation. In this study, we investigated whether the photodegradation of PQ with UV irradiation reduced its toxicity in Drosophila melanogaster. However, dietary ingestion of degradation products PQ for larvae resulted in a low axial ratio (pupal volume). In the adults, products of photodegradation of PQ exposure markedly diminished climbing ability in a time-dependent manner after 10 days of feeding. In addition, exposure of D. melanogaster to photodegradation of PQ reduced acetylcholinesterase and citrate synthase activities but improved oxidative stress, as evidenced by protein carbonyl, and lactate production. These results suggest that the photodegradation of PQ with UV irradiation produced PQ fragments with higher toxicity than PQ, while the precise mechanism of its action needs further investigation.

Publisher

Research Square Platform LLC

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