Changes in the Iris and retinal vessel on optical coherence tomography angiography after intravitreal anti-vascular endothelial growth factor in diabetic macular edema

Author:

Zou H-D1,Jia Yanwen2ORCID,Xue Wenwen1,Tong Xiaowei,Wang Yulan3,Cui Lipu

Affiliation:

1. Shanghai General Hospital

2. Department of Ophthalmology ,Shanghai General Hospital Affiliated Nanjing Medical University, Shanghai, China

3. Shanghai General Hospital Affiliated Nanjing Medical University

Abstract

Abstract Objectives Analyze quantitative changes of iris and retinal vessels in diabetic macular edema (DME) after intravitreal anti-vascular endothelial growth factor (anti-VEGF) and evaluate their correlations. Methods This was a case-cohort study. A total of 26 eyes of DME patients received anti-VEGF treatments and were reviewed three times of follow-up. Images of iris and retinal vessels were obtained before and after treatment and the area density of the vessel (VAD) and the density of the vessel skeleton (VSD) were quantitatively analyzed. Results There was no significant change in the iris VAD after the third injection (p > 0.05), but the VSD of iris decreased (p <0.05). Further linear regression analysis showed that the difference between postoperative and pretreatment iris VSD was negatively correlated with baseline(R = 0.793, B = -1.242, p = 0.000), but not with age, sex, and baseline visual acuity (all p > 0.05). Conclusions Iris vessels are more sensitive to anti-VEGF than retinal vessels.

Publisher

Research Square Platform LLC

Reference17 articles.

1. &Toh N. Angiographic changes in iris and iridocorneal angle neovascularization after intravitreal bevacizumab injection;Ishibashi S;Arch Ophthalmol,2010

2. Conjunctival Microangiopathy in Diabetes Mellitus Assessed with Optical Coherence Tomography Angiography;Schuerch K;Transl Vis Sci Technol,2020

3. &Raman R. Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy;Jain M;Sci Rep,2018

4. &Cetin E. N. Iris thickness measurements in patients with diabetic retinopathy;Demirtas O;Eur J Ophthalmol,2020

5. Chronic changes of the iris microvasculature of streptozotocin-induced diabetic rats using fluorescence videomicroscopy;Jariyapongskul A;Clin Hemorheol Microcirc,2006

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